CLS Technology has managed to develop the world’s purest Beta Glucan (virtually 100% pure), from the medicine mushrooms, called Betox93®. It is soluble, and therefore have a triple helix effect on bio-availability in your body. Thus, the effect is significantly, only after 5-10 min after been eaten, thus, the effect at your immune system is also very effective, also due to the purity. So far we have not seen any other Beta Glucan products in the market have these unique properties. In Japan Beta Glucan it has been used as a medical food the last 20-30 years, to stimulate your innate immune system. The result is that your body is many times able to fight the cancer by itself. As often, pure beta glucan extracted from medical mushrooms are used in combination with chemo and radiotherapy to fight the cancer, with remarkably results. The innate immune system recognize the beta glucans as hostile invaders, but made in the right way will beta-glucans, just as Betox93®, stimulate and strengthen the immune system, and can contribute to fight many diseases and illnesses, or at least that the symptoms are less severe. We recommend a daily dose of 200mg on Betox93® to all healthy adults, to make sure that you are maximizing your innate immune systems. For infants and kids, we recommend 1-2mg per body weight per day. For all adults for the age 50-55, we would strongly recommend a dose of 500mg per day.
For persons taking any drugs, or have any diseases that reduced the immune systems, we would recommend a higher doses, up to 2-8 grams depending on the situation. Betox93® comes in different grades, and can be used in food supplements, food products and also cosmetic formulations. Macrophages, that are part of your immune system, are in your skin and are activated by topical Betox93® just as the internal macrophages are. Our skin is not just a covering for our body; it is the largest organ of the body and the most important organ for our immune systems. The outer layer or epidermis contains about five per cent macrophages. These cells stop the growth of dangerous microbes and produce something called “epidermal growth factor” which stimulates renewal of skin cells. Betox93® are stimulating effective the macrophages in the skin, and make sure that you have the most optimal immunity as you are able to have in your skin. By this, it makes other active skin ingredients work more effective. Thus, Betox93® would be recommended to include in all cosmeceutical products. Our beta glucan is isolated from young and fresh bodies of Oyster mushroom (Pleurolus ostreatus) from controlled farmers in Europe. The raw material for our isolation is grown under the ORGANIC farming standards. On December 3rd 2009 our beta glucan was certified as BIO BETA GLUCAN isolated from BIO Oyster mushroom, certificate No. 317/2009.
Microbial parameters: The product must meet the conditions in Art. 156 of the Codex Alimentarius of the Slovak Republic and Art. II of attachment No. 21 part II of the Food Codex of the Slovak Republic Chemical parameters: The product must meet the conditions contained in part III of the Codex Alimentarius of the Slovak Republic that regulates the appearance of extraneous substances in foodstuffs (Regulation No. 414/2003-100 of the Slovak Ministry of Agriculture and of the Slovak Ministry of Health of February 13, 2003).
Identify: The IR Spectrum of the product must be identical with the IR spectrum of a comparable substance that is declared to be a standard. Sensory parameters: The product is white or light-beige powder with slight bread taste and smell. It is practically insoluble in water, diluted acids, alkaline hydroxides and organic solvents. Expiry: 3 years since the date of production. Packing: Plastic sealed containers for foodstuffs. Storage Conditions: The product must be stored in a dry place and transported under dry conditions protected from sunshine and direct heat. Appropriate storage and transportation temperatures: -15oC to 25oC. High purity – 93% (+/- 2%) of our beta glucan is a guarantee of quality and optimal effect supported by serious amounts of beta glucan in our products. Because of micronisation of beta glucan to particles of 5 μm, the exploitation and bioactivity is significantly improved – particles of beta glucan are able to pass through the villus of the small intestine much more effectively. Long strings of beta glucan are not able to be absorbed in this way – because particles larger than 60 μm cannot be absorbed in the intestine and therefore efficacy of the substance would be greatly reduced. CLS Technology is a primary producer of the beta glucan substance and therefore the price convenience for customer is assured. It is done by low price per 1 mg of high quality active substance (beta glucan) in our products. Product safety is guaranteed – the tablets/capsules production is done under a pharmacological supervision and packaging into blisters. No preservatives and artificial colorants are used in beta glucan substance as well as in the final beta glucan products. These characteristics are guarantee of quality products with exceptional value
Beta 1,3 / 1,6 Glucans
Many polysaccharides and polysaccharide-protein complexes that are used as therapeutic substances have been isolated and examined during the last three decades. The most promising pharmacologic effects of these biopolymers are their ability to modulate the immune system and the anti-cancer effect.
Beta 1,3 / 1,6 glucans have, over the last 50 years, through a series of studies and documentation, proven to be an active substance that has a very positive effect on the immune system, and it is especially the beta 1.3/1.6 glucans that is most effective. Beta glucans are found mostly in yeast and other fungal organisms; best for isolation are dry rot mushrooms. In nature there are also other forms of glucans, mostly of cereal origin (oat and barley), but these are built of glucose units linked with 1,4 bindings.
Mushroom extracts are very well known in the traditional Asian medicine. Usage of these medicinal mushrooms is well documented in japan, USA, Korea, China and Russia. However, only the technical and scientific progress of the extraction techniques in the last thirty years allowed isolation of glucans for medical use and their use in clinical trials.
Glucans have been intensively studied especially because of their most important attribute – the anticancer and immunomodulating effect. Several species of mushrooms were reported to be rich sources of glucans with positive effect on the human, as well as animals´ immune system.
Although there have been identified about 30 species of mushrooms with anti-cancer effect, only few of them were a subject of intense study. The first definitive studies of the anti-cancer mushroom compounds appeared in the late 60´s. It has been proven, that the extracts from various mushrooms species show strong anti-cancer effects. Extraction method was very simple comparing to present-day procedures. It was an extraction by warm water and, in spite of that, it was possible to isolate several polysaccharides. Our sophisticated and patented extraction process allows us to achieve exceptional purity of the isolated beta glucan and because of that high bioactivity is also achieved. By micronization we are able to achieve even higher efficacy and bioactivity of our beta glucan and consequently higher effect on organism.
It is a common understanding among scientists that purity is very important for the efficacy of the beta glucan. Thus, we recommend to us beta glucan that is extracted from the mushrooms, as this beta glucan is the purest. The impurity (fibers and proteins) in the beta glucan products may in fact many times disturb the efficiency to the beta glucan, and make it even less effective. Thus, a beta glucan product that is as close to 100% pure will be preferable and be most effective.
The First Line Defense
Just about every living being, even bacteria and simple plants, have an outer immune system. It is a surface defense that protects the organism against infection and external influences, and includes the mechanical, chemical and biological barriers. The wax layer on the leaves, the peel on shells and insects and skin of animals and people is such an outer defense.
But the skin cannot isolate the human being all the way against the outside world. Therefore, our outer immune system also includes layers that protect the lungs, eyes, nose, ears, stomach/intestines and genital openings. The invaders can be removed mechanically by the sneeze them away or they are killed or isolated by chemical reactions in the body. Tears, breast milk, saliva, gastric acids, sperm and mucus, that is produced in various places in the body, all contains bactericidal killing serums that protect us.
The body’s own bacteria flora (as e.g. in stomach/digestive system) are also an important part of the immune system’s first line of defense, because it competes with the hostile organisms for nourishment, and thereby prevents that the invaders reproduce themselves and get dangerous.
The Innate Defense
In spite of the excellent first line defense, it is inevitable that some pathogens (disease-causing elements such as bacteria and viruses) can manage to take them through the first line defense system. It could be trough a wound, or that the reproduction of the pathogens is too fast and successful. Then the innate defense system takes over. The white blood cells (leukocytes) attack immediately the invaders, either by isolating and then resolve the pathogens, or by “spraying” them with deadly antibodies. The innate defense system is made up of a) the “fixed” system, or the innate immune system, and b) a changeable and adaptable system, or also called the “adaptive immune system. Both of these systems can attack pathogens. All plants and animals have an innate immune system. That act almost instant and in full force. Through evolution over the last millions of years, it has been developed and adapted to the organism to which it lives in, and it is doing a brilliant job. The innate immune system is made up of white blood cells (leukocytes) that move constantly around in the body hunting for harmful invaders. There are many types of leukocytes, each with their specialized task and behavior. Due to the fact that the innate immune system reacts so quickly, it normally takes out the pathogens before they escalate in numbers, and outnumber the leukocytes.
However, bacteria can double about once hour. After 10 hours it is then 1,000 x so many bacteria that originally, and after 24 hours over 1 million times as many. Then it’s easy to understand how important it is that the leukocytes attack immediately.
But also the bacteria adapts and changes over time, and therefore, nature has developed the adaptive immune system, which to a large extent can adapt to the pathogens that are unknown and would have gone clear of the innate immune system.
Adaptive immune systems can be found only at vertebrates. This system attacks with weapons adapted to the specific intruder, and has, in contrast to the innate system, a memory. This means that when the pathogen first is defeated, a later attack by the same (or similar) type of pathogen result in quicker response and faster defeating of the attack. The affected have become immune and will not be sick, or at least less sick than if it had not hosted the attack before.
Also here, there are specialized leukocytes that do the job. However, it is still a lot we don’t understanding about the behavior of the adaptive immune system, but the next paragraph lists up some of the complexity.
The white blood cells (leukocytes) functions of the immune system:
Leukocytes are a particularly important part of the body’s immune system. They are independent cells that move around through the cardiovascular system, the lymphatic system or body tissue on continuous search of pathogens, i.e. alien organisms (viruses, bacteria, parasites, fungi, etc.) that can provoke diseases. Leukocytes are living only a few days.
In the innate immune system:
Phagocytes are formed in the bone marrow, and are able to detect foreign cells and the body’s own cells that are in some way dysfunctional. There are several types of phagocytes:
– The Neutrophils are usually the first to arrive at the scene of an infection
– The Macrophages are wandering around in our body tissue, attacking and isolating the pathogens, and remove the dead body cells.
– The Dent rides cells are located close to the “outside world”, for instant in the skin, the lungs, the nose, and the gastrointestinal/digestive tract. The Dent rides cells gives a signal to the T-cells of the adaptive immune system.
– The Mast cells regulate the immune response, and prevent “exaggerated” allergy reactions.
– The Granulocytes contain granules and cell depleting substances. They are usually the first to come to the infection site. They can be divided into:
– Eosinophils that attacks and destroys the larger penetrating organisms.
– Basophiles that react to allergens and get out histamine, which in turn triggers inflammatory reactions that defense against invading bacteria, viruses, fungi and allergens (allergy-causing substances).
– The NK (Natural Killer-Natural) which does not attack the invading microbes directly, but instead, identify and destroy infected or modified body cells, such as the virus-infected cells, cancer cells, transplanted tissue, etc., the body’s normal and healthy cells is being attacked not by NK-cells.
In the adaptive (tasks and their assigned, specific) the immune system:
Lymphocytes are formed in the bone marrow. The most important thing the lymphocytes are:
– T-cells. They attack cells that are “abnormal”, and regulate the immune response. T-cells are made up of several types:
–Kills-T-cells attack the particular bacteria and viruses by a separate out fabrics that destroys them.
–Help-T-cells determines what type of immune response body will select against a specific invader.
–B-lymphocytes are attacking by forming antibodies such as immunoglobulin and globulin.
The strength of the immune system is changing over time. In particular, the adaptive immune system needs repeated exposures to microbes/pathogens in order to have full effect.
Babies have not had such exposure, and hence their own immune system is not working effectively. Fortunately, the fetus gets immune substances directly from the mother during pregnancy, so that the child has a good concentration of antigens by birth. Breast milk also contains antigens that will be transferred to the baby. Thus, the first few months after it is born, the baby has an usable passively (“borrowed”) immune system, which gradually is replaced by an in-house system as the child’s body teaches itself how to adapt to the surroundings, something it is excellent to do.
The immune system is at the top when you are young. But when one gets older, it starts to get weaker. There are fewer white blood cells, and they are moving more slowly toward the places where they are to combat the unwanted invaders, and the Killer Cells are less toxic. This will give the pathogens a chance to establish and multiply to a greater extent than in young people. For the same reason this makes it easier for cancer diseases to develop and spread in the body. The cells that are made for “memory” in the adaptive immune system are also being fewer and are weaker when one gets older; one thus, get diseases easier.
The risk of getting sick, and more severe and long-lasting sick, increases with age. Vaccines are also less effective for elderly people.
The majority of the researchers believe that the weakening of the immune system by age is evolutionary conditional. It could be that our body is not really meant to live as long as modern medicine and diet allows, and that our immune system is actually forking properly on for the time that the evolution has “assume” that we have a logic to stay alive. That is, to breed us, and then take care of our outcome until they are able to do it themselves. That is, until we are about 50-55 years old.
Disorders in the immune system
In a complex system that our immune system is, it is not difficult to understand that it will have to occur errors and disturbances. Immune interference consists mainly of three groups: defects in the immune system, autoimmunity and hypersensitivity.
Defects in the immune system mean that one or more components in the immune system does not work, or work very badly. There are several types of hereditary genetic defects which can cause this. Today, however, the main cause of the immune defects is bad living conditions and lifestyle, i.e. malnutrition of the child, or alcoholism or drug use by the mother. Mothers who have AIDS (Acquired Immune Deficiency Syndrome) during the pregnancy, will, in approximately 25% of the cases, transfer the disease to the child, who then is born with critical failing immune system.
Autoimmunity refers to a condition in which the adaptive immune system perceives body cells or tissues as foreign invaders and goes to attack them. The autoimmune reaction is triggered when the foreign substance similar to the body’s own structures and the immune system uses a little too “wide” defense, or “must” use a poison against the pathogen that is also harmful to the body itself.
Common autoimmune disease is multiple sclerosis and several kinds of arthritis. Often it is considered also the hereditary skin disease psoriasis as an autoimmune disease.
What triggers the autoimmune reaction is disputed. However, the literature includes a wide range of bacteria as possible causes, including streptococci, borrelia (from flat-bite) and several intestinal bacteria. Psoriasis can be triggered by a variety of factors, including sun and mechanical stress on the skin. Why some people easily get autoimmune reactions than others is not clear. Some autoimmune diseases have been shown to be inhibited or cured by means of antibiotics.
Hypersensitivity is an overreaction of the immune system side that can destroy the body’s own tissues. The symptoms can vary from slight discomfort to life threatening reaction, and the response may occur immediately or several days after the body have been exposed to the causative influence. Allergies are very common types of hypersensitivity. The response to the intruder caused by allergy is immediate (i.e. pollen).